About the Program in Genomic Applications (PGA)

The Variation Discovery Resource project is one of eleven funded Programs for Genomic Applications (PGAs) funded by the National Heart, Lung, and Blood Institute (NHLBI)

Initial sequencing of the human genome - the first step in the full decoding of the genome - is nearing completion. To optimally apply this knowledge, however, scientists must still decipher many of the individual genes and their specific functions. The purpose of the PGAs is to identify the human genes particularly relevant to heart, lung, blood, and sleep functions by expanding upon the data and technologies developed to map and sequence the human genome.

Participants in the NHLBI PGA program include:

• Applied Genomics In Cardiopulmonary Disease - HopGenes
  Director: Joe G. Garcia, M.D., Johns Hopkins University

• Comparative Genomic Analysis Of Cardiovascular Gene Regulation - Berkeley PGA
  Director: Edward M. Rubin, M.D., Ph.D., University of California-Lawrence Berkeley Lab

• Expression Profiling Of Rodent Models Of Human Disease - TREX
  Director: John Quackenbush, Ph.D., The Institute for Genomic Research.

• Genomic Analysis Of Stress And Inflammation - ParaBioSys
  Director: Brian Seed, Ph.D., Massachusetts General Hospital.

• Genomics And Proteomics Of Cell Injury & Inflammation - Southwestern
  Director: Stephen A. Johnston, Ph.D., University of Texas Southwest Medical Center/Dallas

• Genomics Of Cardiovascular Development, Adaptation And Remodeling - CardioGenomics
  Director: Seigo Izumo, M.D., Harvard University Medical School

• Innate Immunity In Heart, Lung, & Blood Disease - InnateImmunity
  Director: Fernando D. Martinez, M.D., University of Arizona

• Mouse Models Of Heart, Lung, And Blood Diseases - JAX PGA
  Director: Luanne L. Peters, Ph.D., Jackson Laboratory

• The NHLBI Bay Area Functional Genomics Consortium - Baygenomics
  Director: Stephen G. Young, M.D., J. David Gladstone Institutes

• Physiogenomics Of Stressors In Derived Consomic Rats - PhysGen
  Director: Howard J. Jacob, Ph.D., Medical College of Wisconsin

• SeattleSNPs Variation Discovery Resource - SeattleSNPs
  Director: Deborah A. Nickerson, Ph.D., University of Washington